Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these sim...

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Detalles Bibliográficos
Autores principales: Vogel, Jacob W., Iturria-Medina, Yasser, Strandberg, Olof T., Smith, Ruben, Levitis, Elizabeth, Evans, Alan C., Hansson, Oskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251068/
https://www.ncbi.nlm.nih.gov/pubmed/32457389
http://dx.doi.org/10.1038/s41467-020-15701-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251068/
https://www.ncbi.nlm.nih.gov/pubmed/32457389
http://dx.doi.org/10.1038/s41467-020-15701-2

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