Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-β-hydroxylase (AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth factor-like domains (EGFDs). AspH is upregulated on the surface of malign cancer cells; increased AspH levels correlate with tumour invasiveness....

Descripción completa

Detalles Bibliográficos
Autores principales: Brewitz, Lennart, Tumber, Anthony, Pfeffer, Inga, McDonough, Michael A., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251097/
https://www.ncbi.nlm.nih.gov/pubmed/32457455
http://dx.doi.org/10.1038/s41598-020-65123-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251097/
https://www.ncbi.nlm.nih.gov/pubmed/32457455
http://dx.doi.org/10.1038/s41598-020-65123-9

Ejemplares similares