Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-H(8)R(8) synergistically kill multi-drug resistant breast cancer cells

Multi-drug resistance (MDR) remains a major obstacle in cancer treatment while being heavily dependent on mitochondrial activity and drug efflux. We previously demonstrated that cationic lipids, such as the vitamin E succinate modified octahistidine-octaarginine (VES-H(8)R(8)) conjugate, target mito...

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Detalles Bibliográficos
Autores principales: Czupiel, Petro, Delplace, Vianney, Shoichet, Molly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251113/
https://www.ncbi.nlm.nih.gov/pubmed/32457422
http://dx.doi.org/10.1038/s41598-020-65450-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251113/
https://www.ncbi.nlm.nih.gov/pubmed/32457422
http://dx.doi.org/10.1038/s41598-020-65450-x

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