Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1

The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and d...

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Detalles Bibliográficos
Autores principales: Mun, Gil-Im, Choi, Eun, Lee, Yeongmin, Lee, Yun-Sil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251134/
https://www.ncbi.nlm.nih.gov/pubmed/32457290
http://dx.doi.org/10.1038/s41419-020-2600-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251134/
https://www.ncbi.nlm.nih.gov/pubmed/32457290
http://dx.doi.org/10.1038/s41419-020-2600-3

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