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Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure
This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251188/ https://www.ncbi.nlm.nih.gov/pubmed/32478209 http://dx.doi.org/10.1016/j.jacbts.2020.03.007 |
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author | Dyavanapalli, Jhansi Rodriguez, Jeannette Rocha dos Santos, Carla Escobar, Joan B. Dwyer, Mary Kate Schloen, John Lee, Kyung-min Wolaver, Whitney Wang, Xin Dergacheva, Olga Michelini, Lisete C. Schunke, Kathryn J. Spurney, Christopher F. Kay, Matthew W. Mendelowitz, David |
author_facet | Dyavanapalli, Jhansi Rodriguez, Jeannette Rocha dos Santos, Carla Escobar, Joan B. Dwyer, Mary Kate Schloen, John Lee, Kyung-min Wolaver, Whitney Wang, Xin Dergacheva, Olga Michelini, Lisete C. Schunke, Kathryn J. Spurney, Christopher F. Kay, Matthew W. Mendelowitz, David |
author_sort | Dyavanapalli, Jhansi |
collection | PubMed |
description | This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic—and decreasing sympathetic—cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure. |
format | Online Article Text |
id | pubmed-7251188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-72511882020-05-29 Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure Dyavanapalli, Jhansi Rodriguez, Jeannette Rocha dos Santos, Carla Escobar, Joan B. Dwyer, Mary Kate Schloen, John Lee, Kyung-min Wolaver, Whitney Wang, Xin Dergacheva, Olga Michelini, Lisete C. Schunke, Kathryn J. Spurney, Christopher F. Kay, Matthew W. Mendelowitz, David JACC Basic Transl Sci PRECLINICAL RESEARCH This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic—and decreasing sympathetic—cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure. Elsevier 2020-05-25 /pmc/articles/PMC7251188/ /pubmed/32478209 http://dx.doi.org/10.1016/j.jacbts.2020.03.007 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | PRECLINICAL RESEARCH Dyavanapalli, Jhansi Rodriguez, Jeannette Rocha dos Santos, Carla Escobar, Joan B. Dwyer, Mary Kate Schloen, John Lee, Kyung-min Wolaver, Whitney Wang, Xin Dergacheva, Olga Michelini, Lisete C. Schunke, Kathryn J. Spurney, Christopher F. Kay, Matthew W. Mendelowitz, David Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure |
title | Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure |
title_full | Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure |
title_fullStr | Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure |
title_full_unstemmed | Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure |
title_short | Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure |
title_sort | activation of oxytocin neurons improves cardiac function in a pressure-overload model of heart failure |
topic | PRECLINICAL RESEARCH |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251188/ https://www.ncbi.nlm.nih.gov/pubmed/32478209 http://dx.doi.org/10.1016/j.jacbts.2020.03.007 |
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