Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction

APOE4 is a major genetic risk factor for Alzheimer's disease and high amyloid-β (Aβ) levels in the brain are a pathological hallmark of the disease. However, the contribution of specific APOE-modulated Aβ-dependent and Aβ-independent functions to cognitive decline remain unclear. Increasing evi...

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Detalles Bibliográficos
Autores principales: Zaldua, Steve, Damen, Frederick C., Pisharody, Rohan, Thomas, Riya, Fan, Kelly D., Ekkurthi, Giri K., Scheinman, Sarah B., Alahmadi, Sami, Marottoli, Felecia M., Alford, Simon, Cai, Kejia, Tai, Leon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251379/
https://www.ncbi.nlm.nih.gov/pubmed/32478184
http://dx.doi.org/10.1016/j.heliyon.2020.e03919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251379/
https://www.ncbi.nlm.nih.gov/pubmed/32478184
http://dx.doi.org/10.1016/j.heliyon.2020.e03919

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