Cargando…

Spred2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by impairing ERK signaling

Downregulation of the sprouty-related EVH1 domain protein 2 (Spred2) is closely associated with highly metastatic phenotypes in various tumors. However, the roles of Spred2 in the development and progression of colorectal cancer (CRC) are still largely unexplored. As anticipated, Spred2 expression w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hao, Liu, Shuchen, Kong, Fanxuan, Xiao, Fengjun, Li, Yuxiang, Wang, Hua, Zhang, Shun, Huang, Dandan, Wang, Lisheng, Yang, Yuefeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251656/ https://www.ncbi.nlm.nih.gov/pubmed/32319644 http://dx.doi.org/10.3892/or.2020.7586

Ejemplares similares

Spred2 Modulates the Erythroid Differentiation Induced by Imatinib in Chronic Myeloid Leukemia Cells
por: Yang, Yuefeng, et al.
Publicado: (2015)

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells
por: Gao, Tong, et al.
Publicado: (2023)

SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation
por: Zhang, Xiaoyan, et al.
Publicado: (2017)

Effect of simulated microgravity conditions of hindlimb unloading on mice hematopoietic and mesenchymal stromal cells
por: Dai, Shiyun, et al.
Publicado: (2020)

Paxillin knockdown suppresses metastasis and epithelial-mesenchymal transition in colorectal cancer via the ERK signalling pathway
por: Wen, Long, et al.
Publicado: (2020)

Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression
por: Sulaiman, Andrew, et al.
Publicado: (2018)

STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways
por: Chen, Bing, et al.
Publicado: (2016)

A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation
por: Takahashi, Sakuma, et al.
Publicado: (2016)

HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling
por: Li, Qinghua, et al.
Publicado: (2017)

Sprouty2 and Spred1-2 Proteins Inhibit the Activation of the ERK Pathway Elicited by Cyclopentenone Prostanoids
por: García-Domínguez, Carlota A., et al.
Publicado: (2011)

ERK signalling modulates epigenome to drive epithelial to mesenchymal transition
por: Navandar, Mohit, et al.
Publicado: (2017)

miR-126-5p affects the chemosensitivity of colorectal cancer cells by regulating SPRED1, ERK1/2 pathway and apoptosis
por: Xu, Mingshi, et al.
Publicado: (2022)

Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer
por: Ding, Chenbo, et al.
Publicado: (2016)

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
por: Yan, Wupeng, et al.
Publicado: (2020)

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma
por: Chen, Lu, et al.
Publicado: (2019)

ATP6L promotes metastasis of colorectal cancer by inducing epithelial‐mesenchymal transition
por: Wang, Jingyi, et al.
Publicado: (2020)

Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways
por: Dong, Shuying, et al.
Publicado: (2013)

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling
por: Bhatt, Akshita B., et al.
Publicado: (2021)

KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition
por: Rao, Chaitra, et al.
Publicado: (2021)

Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
por: Qiao, Lili, et al.
Publicado: (2022)

The SPRED1 Variants Repository for Legius Syndrome
por: Sumner, Kelli, et al.
Publicado: (2011)

Progress in experimental research on SPRED protein family
por: Gong, Jian, et al.
Publicado: (2020)

ANP32A Knockdown Attenuates the Malignant Biological Behavior of Colorectal Cancer Cells by Suppressing Epithelial-mesenchymal Transition and ERK Activation
por: Li, Xiaojuan, et al.
Publicado: (2023)

Role of Epithelial to Mesenchymal Transition in Colorectal Cancer
por: Lu, Jian, et al.
Publicado: (2023)

Therapeutic effects of mesenchymal stem cells loaded with oncolytic adenovirus carrying decorin on a breast cancer lung metastatic mouse model
por: Zhang, Yuning, et al.
Publicado: (2022)

FOXC2 Promotes Oxaliplatin Resistance by Inducing Epithelial-Mesenchymal Transition via MAPK/ERK Signaling in Colorectal Cancer
por: Chen, Yihong, et al.
Publicado: (2020)

miR182 activates the Ras–MEK–ERK pathway in human oral cavity squamous cell carcinoma by suppressing RASA1 and SPRED1
por: Wang, Jinhui, et al.
Publicado: (2017)

Methylation of SPRED1: A New Target in Acute Myeloid Leukemia
por: Su, Nan, et al.
Publicado: (2022)

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer
por: Bhatt, Akshita B., et al.
Publicado: (2021)

The Sprouty/Spred family as tumor suppressors: Coming of age
por: Kawazoe, Tetsuro, et al.
Publicado: (2019)

SPRED proteins and their roles in signal transduction, development, and malignancy
por: Lorenzo, Claire, et al.
Publicado: (2020)

Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder
por: Oda, Shinsuke, et al.
Publicado: (2021)

Dental Pulp Stem Cell-Derived Extracellular Vesicles Mitigate Haematopoietic Damage after Radiation
por: Kong, Fanxuan, et al.
Publicado: (2020)

Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin
por: Kawara, Akina, et al.
Publicado: (2020)

HOXD9 promote epithelial‐mesenchymal transition and metastasis in colorectal carcinoma
por: Liu, Mengwei, et al.
Publicado: (2020)

Beclin1 inhibition promotes autophagy and decreases gemcitabine–induced apoptosis in Miapaca2 pancreatic cancer cells
por: Li, Xiaoshu, et al.
Publicado: (2013)

ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial–mesenchymal transition
por: Liang, Zhaofeng, et al.
Publicado: (2015)

TBX2 overexpression promotes proliferation and invasion through epithelial-mesenchymal transition and ERK signaling pathway
por: Liu, Xingyu, et al.
Publicado: (2019)

HER4 promotes the progression of colorectal cancer by promoting epithelial-mesenchymal transition
por: Jia, Xiaojing, et al.
Publicado: (2020)

ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to-mesenchymal transition
por: Cai, Shurui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j4ecq5g8gf3hifgeonhlebr4rh