Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment

FXS is the most common genetic cause of intellectual (ID) and autism spectrum disorders (ASD). FXS is caused by loss of FMRP, an RNA-binding protein involved in the translational regulation of a large number of neuronal mRNAs. Absence of FMRP has been shown to lead to elevated protein synthesis and...

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Detalles Bibliográficos
Autores principales: Utami, Kagistia Hana, Yusof, Nur Amirah Binte Mohammad, Kwa, Jing Eugene, Peteri, Ulla-Kaisa, Castrén, Maija L., Pouladi, Mahmoud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251671/
https://www.ncbi.nlm.nih.gov/pubmed/32460900
http://dx.doi.org/10.1186/s13229-020-00350-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251671/
https://www.ncbi.nlm.nih.gov/pubmed/32460900
http://dx.doi.org/10.1186/s13229-020-00350-5

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