An elongated tract of polyQ in the carboxyl-terminus of human α1A calcium channel induces cell apoptosis by nuclear translocation

An aberrant elongated tract of glutamine residues (polyQ) in proteins induces multiple diseases treated in the clinic. In our previous study of progressive myoclonic epilepsy (PME), using whole-exome sequencing, a mutant Cav2.1 protein with an aberrant elongated polyQ tract was identified in PME pat...

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Detalles Bibliográficos
Autores principales: Sun, Ji, Sun, Xiguang, Li, Zhuo, Ma, Dihui, Lv, Yudan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251683/
https://www.ncbi.nlm.nih.gov/pubmed/32626992
http://dx.doi.org/10.3892/or.2020.7592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251683/
https://www.ncbi.nlm.nih.gov/pubmed/32626992
http://dx.doi.org/10.3892/or.2020.7592

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