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Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
Optic atrophy 1 (OPA1), a GTPase at the inner mitochondrial membrane involved in regulating mitochondrial fusion, stability, and energy output, is known to be crucial for neural development: Opa1 heterozygous mice show abnormal brain development, and inactivating mutations in OPA1 are linked to huma...
Autores principales: | Caglayan, Safak, Hashim, Adnan, Cieslar-Pobuda, Artur, Jensen, Vidar, Behringer, Sidney, Talug, Burcu, Chu, Dinh Toi, Pecquet, Christian, Rogne, Marie, Brech, Andreas, Brorson, Sverre Henning, Nagelhus, Erlend Arnulf, Hannibal, Luciana, Boschi, Antonella, Taskén, Kjetil, Staerk, Judith |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251951/ https://www.ncbi.nlm.nih.gov/pubmed/32450518 http://dx.doi.org/10.1016/j.isci.2020.101154 |
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