Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model

Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution of CQ and apply it to optimize dosage regimens, a PBPK model, with para...

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Detalles Bibliográficos
Autores principales: Cui, Cheng, Zhang, Miao, Yao, Xueting, Tu, Siqi, Hou, Zhe, Jie En, Valerie Sia, Xiang, Xiaoqiang, Lin, Jing, Cai, Ting, Shen, Ning, Song, Chunli, Qiao, Jie, Zhang, Shun, Li, Haiyan, Liu, Dongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252145/
https://www.ncbi.nlm.nih.gov/pubmed/32834950
http://dx.doi.org/10.1016/j.apsb.2020.04.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252145/
https://www.ncbi.nlm.nih.gov/pubmed/32834950
http://dx.doi.org/10.1016/j.apsb.2020.04.007

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