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Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model

Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution of CQ and apply it to optimize dosage regimens, a PBPK model, with para...

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Detalles Bibliográficos
Autores principales:	Cui, Cheng, Zhang, Miao, Yao, Xueting, Tu, Siqi, Hou, Zhe, Jie En, Valerie Sia, Xiang, Xiaoqiang, Lin, Jing, Cai, Ting, Shen, Ning, Song, Chunli, Qiao, Jie, Zhang, Shun, Li, Haiyan, Liu, Dongyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252145/ https://www.ncbi.nlm.nih.gov/pubmed/32834950 http://dx.doi.org/10.1016/j.apsb.2020.04.007

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