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Metformin Ameliorates Diabetic Cardiomyopathy by Activating the PK2/PKR Pathway

Diabetic cardiomyopathy (DCM) is a complication of diabetes that can cause damage to myocardial structure and function. Metformin (Met) is a widely used type 2 diabetes treatment drug that exerts cardioprotective effects through multiple pathways. Prokineticin 2 (PK2) is a small-molecule secreted pr...

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Detalles Bibliográficos
Autores principales: Yang, Zhen, Wang, Min, Zhang, Yuchen, Cai, Fei, Jiang, Botao, Zha, Wenliang, Yu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252307/
https://www.ncbi.nlm.nih.gov/pubmed/32508669
http://dx.doi.org/10.3389/fphys.2020.00425