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Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma

BACKGROUND: Temozolomide (TMZ) chemotherapy is a current standard of care for glioblastoma (GBM), however it has only extended overall survival by a few months. Because it also modulates the immune system, both beneficially and negatively, understanding how TMZ interacts with immunotherapeutics is i...

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Detalles Bibliográficos
Autores principales: Saha, Dipongkor, Rabkin, Samuel D, Martuza, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252967/
https://www.ncbi.nlm.nih.gov/pubmed/32457126
http://dx.doi.org/10.1136/jitc-2019-000345