Structural basis of broad HIV neutralization by a vaccine-induced cow antibody

Potent broadly neutralizing antibodies (bnAbs) to HIV have been very challenging to elicit by vaccination in wild-type animals. Here, by x-ray crystallography, cryo–electron microscopy, and site-directed mutagenesis, we structurally and functionally elucidate the mode of binding of a potent bnAb (NC...

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Detalles Bibliográficos
Autores principales: Stanfield, Robyn L., Berndsen, Zachary T., Huang, Ruiqi, Sok, Devin, Warner, Gabrielle, Torres, Jonathan L., Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Smider, Vaughn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253169/
https://www.ncbi.nlm.nih.gov/pubmed/32518821
http://dx.doi.org/10.1126/sciadv.aba0468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253169/
https://www.ncbi.nlm.nih.gov/pubmed/32518821
http://dx.doi.org/10.1126/sciadv.aba0468

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