A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl(–)/H(+) transport cycle

Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl(–) for H(+)). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models harmonize with many experimental findings, gaps...

Descripción completa

Detalles Bibliográficos
Autores principales: Chavan, Tanmay S, Cheng, Ricky C, Jiang, Tao, Mathews, Irimpan I, Stein, Richard A, Koehl, Antoine, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253180/
https://www.ncbi.nlm.nih.gov/pubmed/32310757
http://dx.doi.org/10.7554/eLife.53479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253180/
https://www.ncbi.nlm.nih.gov/pubmed/32310757
http://dx.doi.org/10.7554/eLife.53479

Ejemplares similares