Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym

For patients with amyotrophic lateral sclerosis who take oral riluzole tablets, approximately 50% experience alanine transaminase (ALT) levels above upper limit of normal (ULN), 8% above 3× ULN, and 2% above 5× ULN. BHV-0223 is a novel 40 mg rapidly sublingually disintegrating (Zydis) formulation of...

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Detalles Bibliográficos
Autores principales: Longo, Diane M, Shoda, Lisl K M, Howell, Brett A, Coric, Vladimir, Berman, Robert M, Qureshi, Irfan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Organ Specific Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253195/
https://www.ncbi.nlm.nih.gov/pubmed/32040174
http://dx.doi.org/10.1093/toxsci/kfaa019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253195/
https://www.ncbi.nlm.nih.gov/pubmed/32040174
http://dx.doi.org/10.1093/toxsci/kfaa019

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