AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis

Hippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogenesis. YAP1/TEAD complex activates the oncogenic downstream transcription, such as CTGF and c-Myc. How YAP1 is protected in the cytoplasm from ubiquitin-mediated degrada...

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Detalles Bibliográficos
Autores principales: Zhou, Yuhang, Zhang, Jinglin, Li, Hui, Huang, Tingting, Wong, Chi Chun, Wu, Feng, Wu, Man, Weng, Nuoqing, Liu, Liping, Cheng, Alfred S. L., Yu, Jun, Wong, Nathalie, Lo, Kwok Wai, Tang, Patrick M. K., Kang, Wei, To, Ka Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253359/
https://www.ncbi.nlm.nih.gov/pubmed/32313226
http://dx.doi.org/10.1038/s41388-020-1293-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253359/
https://www.ncbi.nlm.nih.gov/pubmed/32313226
http://dx.doi.org/10.1038/s41388-020-1293-5

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