Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F(420)-0 in Mycobacteria

F(420) is a low-potential redox cofactor used by diverse bacteria and archaea. In mycobacteria, this cofactor has multiple roles, including adaptation to redox stress, cell wall biosynthesis, and activation of the clinical antitubercular prodrugs pretomanid and delamanid. A recent biochemical study...

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Detalles Bibliográficos
Autores principales: Grinter, Rhys, Ney, Blair, Brammananth, Rajini, Barlow, Christopher K., Cordero, Paul R. F., Gillett, David L., Izoré, Thierry, Cryle, Max J., Harold, Liam K., Cook, Gregory M., Taiaroa, George, Williamson, Deborah A., Warden, Andrew C., Oakeshott, John G., Taylor, Matthew C., Crellin, Paul K., Jackson, Colin J., Schittenhelm, Ralf B., Coppel, Ross L., Greening, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253369/
https://www.ncbi.nlm.nih.gov/pubmed/32430409
http://dx.doi.org/10.1128/mSystems.00389-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253369/
https://www.ncbi.nlm.nih.gov/pubmed/32430409
http://dx.doi.org/10.1128/mSystems.00389-20

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