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Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F(420)-0 in Mycobacteria
F(420) is a low-potential redox cofactor used by diverse bacteria and archaea. In mycobacteria, this cofactor has multiple roles, including adaptation to redox stress, cell wall biosynthesis, and activation of the clinical antitubercular prodrugs pretomanid and delamanid. A recent biochemical study...
Autores principales: | Grinter, Rhys, Ney, Blair, Brammananth, Rajini, Barlow, Christopher K., Cordero, Paul R. F., Gillett, David L., Izoré, Thierry, Cryle, Max J., Harold, Liam K., Cook, Gregory M., Taiaroa, George, Williamson, Deborah A., Warden, Andrew C., Oakeshott, John G., Taylor, Matthew C., Crellin, Paul K., Jackson, Colin J., Schittenhelm, Ralf B., Coppel, Ross L., Greening, Chris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253369/ https://www.ncbi.nlm.nih.gov/pubmed/32430409 http://dx.doi.org/10.1128/mSystems.00389-20 |
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