hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

RNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo, indicating the existence of poorly characterized molecular machinery that remodels RG4s and maintains them unfolded. Here, we per...

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Detalles Bibliográficos
Autores principales: Herviou, Pauline, Le Bras, Morgane, Dumas, Leïla, Hieblot, Corinne, Gilhodes, Julia, Cioci, Gianluca, Hugnot, Jean-Philippe, Ameadan, Alfred, Guillonneau, François, Dassi, Erik, Cammas, Anne, Millevoi, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253433/
https://www.ncbi.nlm.nih.gov/pubmed/32461552
http://dx.doi.org/10.1038/s41467-020-16168-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253433/
https://www.ncbi.nlm.nih.gov/pubmed/32461552
http://dx.doi.org/10.1038/s41467-020-16168-x

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