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Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian surface epithelium (OSE) are considered the main candidate tissues of origin of this cancer. However, the relative contributio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253462/ https://www.ncbi.nlm.nih.gov/pubmed/32461556 http://dx.doi.org/10.1038/s41467-020-16432-0 |