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Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian surface epithelium (OSE) are considered the main candidate tissues of origin of this cancer. However, the relative contributio...

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Detalles Bibliográficos
Autores principales:	Lõhmussaar, Kadi, Kopper, Oded, Korving, Jeroen, Begthel, Harry, Vreuls, Celien P. H., van Es, Johan H., Clevers, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253462/ https://www.ncbi.nlm.nih.gov/pubmed/32461556 http://dx.doi.org/10.1038/s41467-020-16432-0

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