Cargando…

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic potential. Vaccine development focuses on the principal target of the neutralizing humoral immune response, the spike (S) glycoprotei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watanabe, Yasunori, Berndsen, Zachary T., Raghwani, Jayna, Seabright, Gemma E., Allen, Joel D., Pybus, Oliver G., McLellan, Jason S., Wilson, Ian A., Bowden, Thomas A., Ward, Andrew B., Crispin, Max
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253482/ https://www.ncbi.nlm.nih.gov/pubmed/32461612 http://dx.doi.org/10.1038/s41467-020-16567-0

Ejemplares similares

Structure of the Lassa virus glycan shield provides a model for immunological resistance
por: Watanabe, Yasunori, et al.
Publicado: (2018)

Site-specific analysis of the SARS-CoV-2 glycan shield
por: Watanabe, Yasunori, et al.
Publicado: (2020)

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail
por: Chakraborty, Srirupa, et al.
Publicado: (2020)

Site-specific glycan analysis of the SARS-CoV-2 spike
por: Watanabe, Yasunori, et al.
Publicado: (2020)

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies
por: Pritchard, Laura K., et al.
Publicado: (2015)

Visualization of the HIV-1 Env glycan shield across scales
por: Berndsen, Zachary T., et al.
Publicado: (2020)

Protein and Glycan Mimicry in HIV Vaccine Design
por: Seabright, Gemma E., et al.
Publicado: (2019)

Faster Adaptation in Smaller Populations: Counterintuitive Evolution of HIV during Childhood Infection
por: Raghwani, Jayna, et al.
Publicado: (2016)

Isomer Information from Ion Mobility Separation of High-Mannose Glycan Fragments
por: Harvey, David J., et al.
Publicado: (2018)

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein
por: Casalino, Lorenzo, et al.
Publicado: (2020)

Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein
por: Casalino, Lorenzo, et al.
Publicado: (2020)

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions
por: Seabright, Gemma E., et al.
Publicado: (2020)

Exploitation of glycosylation in enveloped virus pathobiology
por: Watanabe, Yasunori, et al.
Publicado: (2019)

A Molecular-Level Account of the Antigenic Hantaviral Surface
por: Li, Sai, et al.
Publicado: (2016)

A Molecular-Level Account of the Antigenic Hantaviral Surface
por: Li, Sai, et al.
Publicado: (2016)

Extensive weight loss reduces glycan age by altering IgG N-glycosylation
por: Greto, Valentina L., et al.
Publicado: (2021)

The diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2
por: Allen, Joel D., et al.
Publicado: (2023)

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade
por: Bonomelli, Camille, et al.
Publicado: (2011)

The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2
por: Allen, Joel D., et al.
Publicado: (2022)

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
por: Ringe, Rajesh P., et al.
Publicado: (2023)

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection
por: Sommerstein, Rami, et al.
Publicado: (2015)

Conformational Heterogeneity of the HIV Envelope Glycan Shield
por: Yang, Mingjun, et al.
Publicado: (2017)

Glycan shield of the ebolavirus envelope glycoprotein GP
por: Peng, Weiwei, et al.
Publicado: (2022)

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
por: Dubrovskaya, Viktoriya, et al.
Publicado: (2019)

Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike Dynamics
por: Newby, Maddy L., et al.
Publicado: (2023)

Antibody Evasion by a Gammaherpesvirus O-Glycan Shield
por: Machiels, Bénédicte, et al.
Publicado: (2011)

Purifying Selection Determines the Short-Term Time Dependency of Evolutionary Rates in SARS-CoV-2 and pH1N1 Influenza
por: Ghafari, Mahan, et al.
Publicado: (2022)

Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies
por: Wei, Qing, et al.
Publicado: (2020)

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus
por: Allen, Elizabeth R., et al.
Publicado: (2018)

The HIV glycan shield as a target for broadly neutralizing antibodies
por: Doores, Katie J.
Publicado: (2015)

Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies
por: Lavie, Muriel, et al.
Publicado: (2018)

Glycosylator: a Python framework for the rapid modeling of glycans
por: Lemmin, Thomas, et al.
Publicado: (2019)

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging
por: Houvast, Ruben D., et al.
Publicado: (2020)

Glycan Conformation in the Heavily Glycosylated Protein, CEACAM1
por: Rogals, Monique J., et al.
Publicado: (2022)

Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan
por: Ferreira, Roux-Cil, et al.
Publicado: (2018)

Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic
por: Chawla, Himanshi, et al.
Publicado: (2022)

Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies()
por: Le, Ngoc Phuong Lan, et al.
Publicado: (2016)

Deciphering Protein Glycosylation by Computational Integration of On-chip Profiling, Glycan-array Data, and Mass Spectrometry
por: Klamer, Zachary, et al.
Publicado: (2019)

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
por: Julien, J, et al.
Publicado: (2012)

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen
por: Struwe, Weston B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_cq66h9rf7c678jn1kor0n2fcpn