Hyaluronidase-2 Regulates RhoA Signaling, Myofibroblast Contractility, and Other Key Profibrotic Myofibroblast Functions

Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive; thus the mechanisms through which HYAL2 dysregulation i...

Descripción completa

Detalles Bibliográficos
Autores principales: Midgley, Adam C., Woods, Emma L., Jenkins, Robert H., Brown, Charlotte, Khalid, Usman, Chavez, Rafael, Hascall, Vincent, Steadman, Robert, Phillips, Aled O., Meran, Soma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254050/
https://www.ncbi.nlm.nih.gov/pubmed/32201263
http://dx.doi.org/10.1016/j.ajpath.2020.02.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254050/
https://www.ncbi.nlm.nih.gov/pubmed/32201263
http://dx.doi.org/10.1016/j.ajpath.2020.02.012

Ejemplares similares