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Hyaluronidase-2 Regulates RhoA Signaling, Myofibroblast Contractility, and Other Key Profibrotic Myofibroblast Functions

Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive; thus the mechanisms through which HYAL2 dysregulation i...

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Detalles Bibliográficos
Autores principales:	Midgley, Adam C., Woods, Emma L., Jenkins, Robert H., Brown, Charlotte, Khalid, Usman, Chavez, Rafael, Hascall, Vincent, Steadman, Robert, Phillips, Aled O., Meran, Soma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Investigative Pathology 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254050/ https://www.ncbi.nlm.nih.gov/pubmed/32201263 http://dx.doi.org/10.1016/j.ajpath.2020.02.012

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