Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A

The protein p27, a prominent regulatory protein in eukaryotes and an intrinsically disordered protein (IDP), regulates cell division by causing cell cycle arrest when bound in ternary complex with cyclin-dependent kinase (Cdk2) and cyclins (e.g., Cdk2/Cyclin A). We present an integrative study of p2...

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Detalles Bibliográficos
Autores principales: Tsytlonok, Maksym, Hemmen, Katherina, Hamilton, George, Kolimi, Narendar, Felekyan, Suren, Seidel, Claus A.M., Tompa, Peter, Sanabria, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254055/
https://www.ncbi.nlm.nih.gov/pubmed/32088186
http://dx.doi.org/10.1016/j.jmb.2020.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254055/
https://www.ncbi.nlm.nih.gov/pubmed/32088186
http://dx.doi.org/10.1016/j.jmb.2020.02.010

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