AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity

Rhodopsin misfolding caused by the P23H mutation is a major cause of autosomal dominant retinitis pigmentosa (adRP). To date, there are no effective treatments for adRP. The BiP co-chaperone and reductase ERdj5 (DNAJC10) is part of the endoplasmic reticulum (ER) quality control machinery, and previo...

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Detalles Bibliográficos
Autores principales: Aguilà, Monica, Bellingham, James, Athanasiou, Dimitra, Bevilacqua, Dalila, Duran, Yanai, Maswood, Ryea, Parfitt, David A, Iwawaki, Takao, Spyrou, Giannis, Smith, Alexander J, Ali, Robin R, Cheetham, Michael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254845/
https://www.ncbi.nlm.nih.gov/pubmed/32196553
http://dx.doi.org/10.1093/hmg/ddaa049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254845/
https://www.ncbi.nlm.nih.gov/pubmed/32196553
http://dx.doi.org/10.1093/hmg/ddaa049

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