Cargando…

Non-canonical signaling pathway of SNAI2 induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10

Background: Epithelial ovarian cancer (EOC) is one of the most lethal malignancies in women worldwide. Many studies showed the transcription factor SNAI2-induced Epithelial-Mesenchymal Transition (EMT) through inhibiting E-cadherin (E-cad) expression. Our previous study reported that miR-222-3p was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Lili, Lei, Han, Zhang, Sai, Peng, Yulong, Fu, Chunyan, Shu, Guang, Yin, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254989/ https://www.ncbi.nlm.nih.gov/pubmed/32483426 http://dx.doi.org/10.7150/thno.43198

Ejemplares similares

HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer
por: Peng, Yulong, et al.
Publicado: (2020)

SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma
por: Hsiao, Yi-Jing, et al.
Publicado: (2016)

PDCD10 promotes proliferation, migration, and invasion of osteosarcoma by inhibiting apoptosis and activating EMT pathway
por: Xu, Ke, et al.
Publicado: (2022)

miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27(kip1)
por: SUN, CHAOYANG, et al.
Publicado: (2013)

Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis
por: Fan, Lili, et al.
Publicado: (2022)

FBXL10 promotes EMT and metastasis of breast cancer cells via regulating the acetylation and transcriptional activity of SNAI1
por: Yang, Yangyang, et al.
Publicado: (2021)

MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1
por: Zhang, Xianglian, et al.
Publicado: (2022)

Anti-tumor effect of HOTAIR–miR-613-SNAI2 axis through suppressing EMT and drug resistance in laryngeal squamous cell carcinoma
por: Zhou, Jing-chun, et al.
Publicado: (2018)

Author Correction: FBXL10 promotes EMT and metastasis of breast cancer cells via regulating the acetylation and transcriptional activity of SNAI1
por: Yang, Yangyang, et al.
Publicado: (2022)

DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
por: Mitchell, Allison V., et al.
Publicado: (2022)

EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway
por: Wang, Yuanyang, et al.
Publicado: (2023)

The multifaceted PDCD10/CCM3 gene
por: Valentino, Mariaelena, et al.
Publicado: (2020)

SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition
por: Sundararajan, Vignesh, et al.
Publicado: (2019)

SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2
por: Sundararajan, Vignesh, et al.
Publicado: (2020)

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression
por: Gentile, Alessandra, et al.
Publicado: (2021)

FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2
por: Chen, Yang, et al.
Publicado: (2021)

The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma
por: JIKUZONO, TOMOO, et al.
Publicado: (2013)

SNAI2 promotes the development of ovarian cancer through regulating ferroptosis
por: Jin, Yunfeng, et al.
Publicado: (2022)

SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC
por: Hasmim, Meriem, et al.
Publicado: (2022)

Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression
por: Yang, Zongyuan, et al.
Publicado: (2017)

Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer
por: De Marco, Carmela, et al.
Publicado: (2021)

Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice
por: Jiang, Xiuli, et al.
Publicado: (2018)

miR-222 promotes invasion and migration of ovarian carcinoma by targeting PTEN
por: Gong, Li, et al.
Publicado: (2018)

PDCD10 Gene Mutations in Multiple Cerebral Cavernous Malformations
por: Cigoli, Maria Sole, et al.
Publicado: (2014)

Deletion of Snai2 and Snai3 Results in Impaired Physical Development Compounded by Lymphocyte Deficiency
por: Pioli, Peter D., et al.
Publicado: (2013)

Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer
por: Wei, Na, et al.
Publicado: (2012)

Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis
por: Ge, Xiaolu, et al.
Publicado: (2019)

miR-21, miR-221, and miR-222 upregulation in lung cancer promotes metastasis by reducing oxidative stress and apoptosis
por: Tepebaşı, Muhammet Yusuf, et al.
Publicado: (2023)

miR302 regulates SNAI1 expression to control mesangial cell plasticity
por: De Chiara, L., et al.
Publicado: (2017)

SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition
por: Jia, Zhuqing, et al.
Publicado: (2015)

Correction: PDCD10 Gene Mutations in Multiple Cerebral Cavernous Malformations
Publicado: (2015)

The Dual Role of PDCD10 in Cancers: A Promising Therapeutic Target
por: Liu, Jingdian, et al.
Publicado: (2022)

LINC00974 sponges miR-33a to facilitate cell proliferation, invasion, and EMT of ovarian cancer through HMGB2 upregulation
por: Liu, Weiwei, et al.
Publicado: (2022)

Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair
por: Wang, Tao, et al.
Publicado: (2015)

SNAI1 and SNAI2 Are Asymmetrically Expressed at the 2-Cell Stage and Become Segregated to the TE in the Mouse Blastocyst
por: Bell, Christine E., et al.
Publicado: (2009)

Absence of a Major Role for the Snai1 and Snai3 Genes in Regulating Skeletal Muscle Regeneration in Mice
por: Norton, Christine R., et al.
Publicado: (2013)

PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer
por: Su, Dan, et al.
Publicado: (2012)

Upregulation of Synuclein-γ and Snai1 Contributes to Poor Clinical Prognosis in Oral Squamous Cell Carcinoma Patients
por: Yang, Jie, et al.
Publicado: (2022)

The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion
por: Fenouille, Nina, et al.
Publicado: (2012)

The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism
por: Zheng, Xin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a5l4j666rmjbdn5aantllhp9ou