Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D(3) in colorectal cancer

Colorectal cancer (CRC) is the leading cause of cancer death; however, targets with broad anti-CRC effects are limited. Sirtuin6 (SIRT6) is a conserved nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase that is widely pathologically downregulated in CRC, but its pharmacological effect...

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Detalles Bibliográficos
Autores principales: Shang, Jialin, Zhu, Zhehui, Chen, Yingyi, Song, Jinglue, Huang, Yuji, Song, Kun, Zhong, Jie, Xu, Xinyuan, Wei, Jiacheng, Wang, Chengxiang, Cui, Long, Liu, Chen-Ying, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255010/
https://www.ncbi.nlm.nih.gov/pubmed/32483423
http://dx.doi.org/10.7150/thno.44043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255010/
https://www.ncbi.nlm.nih.gov/pubmed/32483423
http://dx.doi.org/10.7150/thno.44043

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