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Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D(3) in colorectal cancer
Colorectal cancer (CRC) is the leading cause of cancer death; however, targets with broad anti-CRC effects are limited. Sirtuin6 (SIRT6) is a conserved nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase that is widely pathologically downregulated in CRC, but its pharmacological effect...
Autores principales: | Shang, Jialin, Zhu, Zhehui, Chen, Yingyi, Song, Jinglue, Huang, Yuji, Song, Kun, Zhong, Jie, Xu, Xinyuan, Wei, Jiacheng, Wang, Chengxiang, Cui, Long, Liu, Chen-Ying, Zhang, Jian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255010/ https://www.ncbi.nlm.nih.gov/pubmed/32483423 http://dx.doi.org/10.7150/thno.44043 |
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