Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity

The apicomplexan Toxoplasma gondii induces strong protective immunity dependent upon recognition by Toll-like receptors (TLR)11 and 12 operating in conjunction with MyD88 in the murine host. However, TLR11 and 12 proteins are not present in humans, inspiring us to investigate MyD88-independent pathw...

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Detalles Bibliográficos
Autores principales: Mercer, Heather L., Snyder, Lindsay M., Doherty, Claire M., Fox, Barbara A., Bzik, David J., Denkers, Eric Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255617/
https://www.ncbi.nlm.nih.gov/pubmed/32413093
http://dx.doi.org/10.1371/journal.ppat.1008572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255617/
https://www.ncbi.nlm.nih.gov/pubmed/32413093
http://dx.doi.org/10.1371/journal.ppat.1008572

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