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Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca(2+) permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated with intellectual disability and epilepsy; the func...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255801/ https://www.ncbi.nlm.nih.gov/pubmed/32343227 http://dx.doi.org/10.7554/eLife.55634 |