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Defining the Design Parameters for in Vivo Enzyme Delivery Through Protein Spherical Nucleic Acids

[Image: see text] The translation of proteins as effective intracellular drug candidates is limited by the challenge of cellular entry and their vulnerability to degradation. To advance their therapeutic potential, cell-impermeable proteins can be readily transformed into protein spherical nucleic a...

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Detalles Bibliográficos
Autores principales: Kusmierz, Caroline D., Bujold, Katherine E., Callmann, Cassandra E., Mirkin, Chad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256953/
https://www.ncbi.nlm.nih.gov/pubmed/32490197
http://dx.doi.org/10.1021/acscentsci.0c00313