The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs

OBJECTIVE: To explore the possibility and mechanism of targeted blocking SDF-1/CXCR4 signaling pathway using three antagonists TN14003, T140, and AMD3100 in vivo, and to investigate the function of three antagonists in delay degeneration process of articular cartilage. METHODS: Ninety-six male Dunca...

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Detalles Bibliográficos
Autores principales: Wang, Guoliang, Li, Yanlin, Meng, Xuhan, Yang, Xiao, Xiang, Yaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257224/
https://www.ncbi.nlm.nih.gov/pubmed/32471458
http://dx.doi.org/10.1186/s13018-020-01646-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257224/
https://www.ncbi.nlm.nih.gov/pubmed/32471458
http://dx.doi.org/10.1186/s13018-020-01646-1

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