ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4(+) T cells

BACKGROUND: Sepsis-associated encephalopathy (SAE) increases the mortality of septic patients, but its mechanism remains unclear. The present study aimed to investigate the roles of T lymphocytes, proBDNF, and their interaction in the pathogenesis of SAE. METHODS: Fear conditioning tests were conduc...

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Detalles Bibliográficos
Autores principales: Luo, Ru-Yi, Luo, Cong, Zhong, Feng, Shen, Wei-Yun, Li, Hui, Hu, Zhao-Lan, Dai, Ru-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257240/
https://www.ncbi.nlm.nih.gov/pubmed/32466783
http://dx.doi.org/10.1186/s12974-020-01850-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257240/
https://www.ncbi.nlm.nih.gov/pubmed/32466783
http://dx.doi.org/10.1186/s12974-020-01850-0

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