No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease

We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephal...

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Autores principales: Boyle, Aileen, Plinston, Chris, Laing, Fraser, Mackenzie, Graeme, Will, Robert G., Manson, Jean C., Diack, Abigail B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258451/
https://www.ncbi.nlm.nih.gov/pubmed/32441626
http://dx.doi.org/10.3201/eid2606.191116
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author Boyle, Aileen
Plinston, Chris
Laing, Fraser
Mackenzie, Graeme
Will, Robert G.
Manson, Jean C.
Diack, Abigail B.
author_facet Boyle, Aileen
Plinston, Chris
Laing, Fraser
Mackenzie, Graeme
Will, Robert G.
Manson, Jean C.
Diack, Abigail B.
author_sort Boyle, Aileen
collection PubMed
description We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background.
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spelling pubmed-72584512020-06-09 No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease Boyle, Aileen Plinston, Chris Laing, Fraser Mackenzie, Graeme Will, Robert G. Manson, Jean C. Diack, Abigail B. Emerg Infect Dis Dispatch We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background. Centers for Disease Control and Prevention 2020-06 /pmc/articles/PMC7258451/ /pubmed/32441626 http://dx.doi.org/10.3201/eid2606.191116 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Boyle, Aileen
Plinston, Chris
Laing, Fraser
Mackenzie, Graeme
Will, Robert G.
Manson, Jean C.
Diack, Abigail B.
No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
title No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
title_full No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
title_fullStr No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
title_full_unstemmed No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
title_short No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
title_sort no adaptation of the prion strain in a heterozygous case of variant creutzfeldt-jakob disease
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258451/
https://www.ncbi.nlm.nih.gov/pubmed/32441626
http://dx.doi.org/10.3201/eid2606.191116
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