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Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

INTRODUCTION: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. METHODS: We de...

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Autores principales: Schmitt, Christina, Lechanteur, Anna, Cossais, François, Bellefroid, Coralie, Arnold, Philipp, Lucius, Ralph, Held-Feindt, Janka, Piel, Geraldine, Hattermann, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259452/
https://www.ncbi.nlm.nih.gov/pubmed/32547020
http://dx.doi.org/10.2147/IJN.S245300
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author Schmitt, Christina
Lechanteur, Anna
Cossais, François
Bellefroid, Coralie
Arnold, Philipp
Lucius, Ralph
Held-Feindt, Janka
Piel, Geraldine
Hattermann, Kirsten
author_facet Schmitt, Christina
Lechanteur, Anna
Cossais, François
Bellefroid, Coralie
Arnold, Philipp
Lucius, Ralph
Held-Feindt, Janka
Piel, Geraldine
Hattermann, Kirsten
author_sort Schmitt, Christina
collection PubMed
description INTRODUCTION: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. METHODS: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis. RESULTS: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices. DISCUSSION AND PERSPECTIVE: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.
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spelling pubmed-72594522020-06-15 Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices Schmitt, Christina Lechanteur, Anna Cossais, François Bellefroid, Coralie Arnold, Philipp Lucius, Ralph Held-Feindt, Janka Piel, Geraldine Hattermann, Kirsten Int J Nanomedicine Original Research INTRODUCTION: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. METHODS: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis. RESULTS: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices. DISCUSSION AND PERSPECTIVE: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials. Dove 2020-05-25 /pmc/articles/PMC7259452/ /pubmed/32547020 http://dx.doi.org/10.2147/IJN.S245300 Text en © 2020 Schmitt et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Schmitt, Christina
Lechanteur, Anna
Cossais, François
Bellefroid, Coralie
Arnold, Philipp
Lucius, Ralph
Held-Feindt, Janka
Piel, Geraldine
Hattermann, Kirsten
Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_full Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_fullStr Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_full_unstemmed Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_short Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_sort liposomal encapsulated curcumin effectively attenuates neuroinflammatory and reactive astrogliosis reactions in glia cells and organotypic brain slices
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259452/
https://www.ncbi.nlm.nih.gov/pubmed/32547020
http://dx.doi.org/10.2147/IJN.S245300
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