Increased effect of two-fraction radiotherapy in conjunction with IDO1 inhibition in experimental glioblastoma

OBJECTIVES: The aim of the study was to investigate therapeutic efficacy of single- or two-fraction radiotherapy in conjunction with IDO1-inhibition in a syngeneic rat glioblastoma model. IDO is known to cause immunosuppression through breakdown of tryptophan in the tumor microenvironment. METHODS:...

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Detalles Bibliográficos
Autores principales: Ahlstedt, Jonatan, Konradsson, Elise, Ceberg, Crister, Redebrandt, Henrietta Nittby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259656/
https://www.ncbi.nlm.nih.gov/pubmed/32469935
http://dx.doi.org/10.1371/journal.pone.0233617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259656/
https://www.ncbi.nlm.nih.gov/pubmed/32469935
http://dx.doi.org/10.1371/journal.pone.0233617

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