Emergence of prions selectively resistant to combination drug therapy

Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrP(Sc). Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been dev...

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Detalles Bibliográficos
Autores principales: Burke, Cassandra M., Mark, Kenneth M. K., Kun, Judit, Beauchemin, Kathryn S., Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259791/
https://www.ncbi.nlm.nih.gov/pubmed/32421750
http://dx.doi.org/10.1371/journal.ppat.1008581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259791/
https://www.ncbi.nlm.nih.gov/pubmed/32421750
http://dx.doi.org/10.1371/journal.ppat.1008581

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