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Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia
Acute myeloid leukemia (AML) disrupts the generation of normal blood cells, predisposing patients to hemorrhage, anemia, and infections. Differentiation and proliferation of residual normal hematopoietic stem and progenitor cells (HSPCs) are impeded in AML-infiltrated bone marrow (BM). The underlyin...
Autores principales: | Waclawiczek, Alexander, Hamilton, Ashley, Rouault-Pierre, Kevin, Abarrategi, Ander, Albornoz, Manuel Garcia, Miraki-Moud, Farideh, Bah, Nourdine, Gribben, John, Fitzgibbon, Jude, Taussig, David, Bonnet, Dominique |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260026/ https://www.ncbi.nlm.nih.gov/pubmed/32364536 http://dx.doi.org/10.1172/JCI133187 |
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