Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system

We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical transcranial MRI-guided focused ultrasound (TcMRgFUS) device and evaluated enhanced delivery of irinotecan chemotherapy to the brain and a rat glioma model. Animals received three weekly sessions of FUS, F...

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Detalles Bibliográficos
Autores principales: McDannold, Nathan, Zhang, Yongzhi, Supko, Jeffrey G., Power, Chanikarn, Sun, Tao, Vykhodtseva, Natalia, Golby, Alexandra J., Reardon, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260193/
https://www.ncbi.nlm.nih.gov/pubmed/32472017
http://dx.doi.org/10.1038/s41598-020-65617-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260193/
https://www.ncbi.nlm.nih.gov/pubmed/32472017
http://dx.doi.org/10.1038/s41598-020-65617-6

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