Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase

The acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein interactions. Here, using electron cryo-microscopy (cryoEM), we report the structure of a fungal FAS stalled at the dehydration reaction, which pre...

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Detalles Bibliográficos
Autores principales: Lou, Jennifer W., Mazhab-Jafari, Mohammad T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260205/
https://www.ncbi.nlm.nih.gov/pubmed/32471977
http://dx.doi.org/10.1038/s42003-020-0997-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260205/
https://www.ncbi.nlm.nih.gov/pubmed/32471977
http://dx.doi.org/10.1038/s42003-020-0997-y

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