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Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase

The acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein interactions. Here, using electron cryo-microscopy (cryoEM), we report the structure of a fungal FAS stalled at the dehydration reaction, which pre...

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Detalles Bibliográficos
Autores principales:	Lou, Jennifer W., Mazhab-Jafari, Mohammad T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260205/ https://www.ncbi.nlm.nih.gov/pubmed/32471977 http://dx.doi.org/10.1038/s42003-020-0997-y

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