Signal profiling of the β(1)AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β(1)AR and β(2)AR

A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established pathways. Here, using an array of sixteen validated BRET-based biosensors, we analyzed the ability of seven different β-adrenergic ligands to en...

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Detalles Bibliográficos
Autores principales: Lukasheva, Viktoriya, Devost, Dominic, Le Gouill, Christian, Namkung, Yoon, Martin, Ryan D., Longpré, Jean-Michel, Amraei, Mohammad, Shinjo, Yuji, Hogue, Mireille, Lagacé, Monique, Breton, Billy, Aoki, Junken, Tanny, Jason C., Laporte, Stéphane A., Pineyro, Graciela, Inoue, Asuka, Bouvier, Michel, Hébert, Terence E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260363/
https://www.ncbi.nlm.nih.gov/pubmed/32471984
http://dx.doi.org/10.1038/s41598-020-65636-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260363/
https://www.ncbi.nlm.nih.gov/pubmed/32471984
http://dx.doi.org/10.1038/s41598-020-65636-3

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