Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells

PURPOSE: Autophagy caused by ischemia/reperfusion (I/R) increases the extent of cardiomyocyte damage. Melatonin (Mel) diminishes cardiac injury through regulating autophagy and mitochondrial dynamics. However, illustrating the specific role of mitophagy in the cardioprotective effects of melatonin r...

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Detalles Bibliográficos
Autores principales: Wu, Jinjing, Yang, Yanli, Gao, Yafen, Wang, Zhaoqi, Ma, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260543/
https://www.ncbi.nlm.nih.gov/pubmed/32546969
http://dx.doi.org/10.2147/DDDT.S248628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260543/
https://www.ncbi.nlm.nih.gov/pubmed/32546969
http://dx.doi.org/10.2147/DDDT.S248628

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