Coevolutionary data-based interaction networks approach highlighting key residues across protein families: The case of the G-protein coupled receptors

We present an approach that, by integrating structural data with Direct Coupling Analysis, is able to pinpoint most of the interaction hotspots (i.e. key residues for the biological activity) across very sparse protein families in a single run. An application to the Class A G-protein coupled recepto...

Descripción completa

Detalles Bibliográficos
Autores principales: Baldessari, Filippo, Capelli, Riccardo, Carloni, Paolo, Giorgetti, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260681/
https://www.ncbi.nlm.nih.gov/pubmed/32489528
http://dx.doi.org/10.1016/j.csbj.2020.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260681/
https://www.ncbi.nlm.nih.gov/pubmed/32489528
http://dx.doi.org/10.1016/j.csbj.2020.05.003

Ejemplares similares