Phosphorothioate modified oligonucleotide–protein interactions

Antisense oligonucleotides (ASOs) interact with target RNAs via hybridization to modulate gene expression through different mechanisms. ASO therapeutics are chemically modified and include phosphorothioate (PS) backbone modifications and different ribose and base modifications to improve pharmacolog...

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Detalles Bibliográficos
Autores principales: Crooke, Stanley T, Vickers, Timothy A, Liang, Xue-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261153/
https://www.ncbi.nlm.nih.gov/pubmed/32356888
http://dx.doi.org/10.1093/nar/gkaa299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261153/
https://www.ncbi.nlm.nih.gov/pubmed/32356888
http://dx.doi.org/10.1093/nar/gkaa299

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