Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA

The CRISPR-Cas9 system has been used for genome editing of various organisms. We reported inhibition of the human immunodeficiency virus (HIV) in cell culture infections with a single guide RNA (gRNA) and subsequent viral escape, but complete inactivation of infectious HIV with certain combinations...

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Detalles Bibliográficos
Autores principales: Gao, Zongliang, Fan, Minghui, Das, Atze T, Herrera-Carrillo, Elena, Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261156/
https://www.ncbi.nlm.nih.gov/pubmed/32282899
http://dx.doi.org/10.1093/nar/gkaa226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261156/
https://www.ncbi.nlm.nih.gov/pubmed/32282899
http://dx.doi.org/10.1093/nar/gkaa226

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