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Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA
The CRISPR-Cas9 system has been used for genome editing of various organisms. We reported inhibition of the human immunodeficiency virus (HIV) in cell culture infections with a single guide RNA (gRNA) and subsequent viral escape, but complete inactivation of infectious HIV with certain combinations...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261156/ https://www.ncbi.nlm.nih.gov/pubmed/32282899 http://dx.doi.org/10.1093/nar/gkaa226 |